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Performing being an NMDA antagonist could be 1 system by which methadone decreases craving for opioids and tolerance, and has become proposed like a probable system for its distinguished efficacy regarding the procedure of neuropathic suffering.[citation required] Methadone also acted as being a strong, noncompetitive α3β4 neuronal nicotinic acetylcholine receptor antagonist in rat receptors, expressed in human embryonic kidney cell lines.[62]
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